What Is A Good Pasteur’s Syndrome?
It is defined as a disorder in which there is an involvement of the kidneys as well as lungs. It is also known as the anti glomerular basement membrane disease. It increases with the immune response and the antigen of good pasture is attacked. It occurs in the lungs as well as kidneys. It is named after Dr E Good pasture. It was described in the year 1919. This type of antigen is a component of the collagen.
What are the signs and symptoms of Good Pasteur’s syndrome?
It includes the coughing of blood from the people. There is a burning sensation when the person urinates. One can also notice fatigue, nausea and problem in the breathing. The kidney is involved later on with the presence of blood in urine along with the presence of protein in the urine. It can be confirmed by the laboratory as well as clinical findings. Some of the patients have one disease and some of them have a combination of both. The first organ which is affected is the lungs and is followed by the kidneys.
What are the causes of Good Pasteur’s syndrome?
It includes the most common component of exposure to chemicals. It includes the weed killers, solvents as well as viral infections. The lung disease can lead to coughlessness and dry breath. These symptoms are present for many years. The lung damage can cause problem in the supply of oxygen and sometimes the blood is present in the sputum. It is known as hemoptysis. If it persists for long time than there is a loss of blood and is known as anemia. The lungs are lost as fast as kidneys. In smokers there is an occurrence of blood from the lungs. There can be a lung infection also in later cases. In kidneys glomeruli are involved which leads to nephritis. There is a loss of kidney function in few days. It is known as rapidly progressive glomerulo nephritis and is referred as the RPGN. In the urine the blood occurs and is known as hematuria. The urine output and the urea decreases and the products are excreted by the kidney. These are present in the blood and are referred as the acute renal failure. It does not cause any symptoms and there is a lost of kidney function. There is a loss of kidney function as well as malaise and in severe cases the blood pressure increases and may lead to edema. There is a nephritic syndrome in which there is a secretion of blood in the urine and there is a high blood pressure with a decrease in glomerular filtration rate. It is different to nephritic syndrome. In this a large amount of protein is secreted in the urine and there is a severe edema.
How Good Pasteur’s syndrome can be diagnosed?
It includes the use of visual examination and a patient history. It is difficult to diagnose as the symptoms are vague. One can go for the kidney biopsy if there is a need for it. This condition is diagnosed in the later stages. The kidney biopsy tells us about the extension of disease and its effect of treatment. There are few tests which have been proved to be quite effective and include the anti GBM antibodies test etc. These act against the patient’s own protein.
How Good pasteurs syndrome can be treated?
One can treat is with the help of cortico steroids as well as the use of immune globins intravenously. Most of the patients have a full function capacity. In case if there are complications in the lung it may lead to death. One must go for a supportive care and monitor all the vital functions. One must keep a check on the respiratory failure and there must be an early intubation. The anti GBM antibodies decrease the apheresis as that the blood plasma can be removed. It is replaced by the plasma with an isotonic salt as well as protein solution. This type of treatment is given for 3 to 6 months. The permanent damage to kidney cannot be treated and the method of treatment is transplantation of the kidney. It must be done when the disease is under control.